Since the enforcement of regulation prohibiting the use of animal or animal derived substances for the development and testing of consumer, cosmetic and pharmaceutical ingredients (EU regulation 76/768/EEC), there has been considerable focus on the development, evaluation and integration of alternative approaches (e.g. in silico approaches such as (Q)SARs and expert systems) for skin sensitization hazard and risk assessment. These studies open an interesting window for INTUITIVE as they could be extended to develop the in-silico model of skin to investigate the transduction mechanism in soft-skin at molecular scale. The fellow involved in this project will develop the in-silico models of skin by considering the receptors in soft skin at various depths and role of various soft materials. Here we will incorporate new findings in the synthetic material to be used for making of artificial tactile sensing skin.